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ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

With the advent of new agents targeting CD20, Bruton’s tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibi...

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Detalles Bibliográficos
Autores principales:	Cang, Shundong, Iragavarapu, Chaitanya, Savooji, John, Song, Yongping, Liu, Delong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654800/ https://www.ncbi.nlm.nih.gov/pubmed/26589495 http://dx.doi.org/10.1186/s13045-015-0224-3

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