Cargando…
Normal values for pancreatic stone protein in different age groups
BACKGROUND: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP. METHODS: PSP was determined using a speci...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654823/ https://www.ncbi.nlm.nih.gov/pubmed/26588901 http://dx.doi.org/10.1186/s12871-015-0149-y |
_version_ | 1782402107067858944 |
---|---|
author | Schlapbach, Luregn J Giannoni, Eric Wellmann, Sven Stocker, Martin Ammann, Roland A Graf, Rolf |
author_facet | Schlapbach, Luregn J Giannoni, Eric Wellmann, Sven Stocker, Martin Ammann, Roland A Graf, Rolf |
author_sort | Schlapbach, Luregn J |
collection | PubMed |
description | BACKGROUND: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP. METHODS: PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations. RESULTS: PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %). CONCLUSIONS: This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood. |
format | Online Article Text |
id | pubmed-4654823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46548232015-11-22 Normal values for pancreatic stone protein in different age groups Schlapbach, Luregn J Giannoni, Eric Wellmann, Sven Stocker, Martin Ammann, Roland A Graf, Rolf BMC Anesthesiol Research Article BACKGROUND: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP. METHODS: PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations. RESULTS: PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %). CONCLUSIONS: This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood. BioMed Central 2015-11-20 /pmc/articles/PMC4654823/ /pubmed/26588901 http://dx.doi.org/10.1186/s12871-015-0149-y Text en © Schlapbach et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Schlapbach, Luregn J Giannoni, Eric Wellmann, Sven Stocker, Martin Ammann, Roland A Graf, Rolf Normal values for pancreatic stone protein in different age groups |
title | Normal values for pancreatic stone protein in different age groups |
title_full | Normal values for pancreatic stone protein in different age groups |
title_fullStr | Normal values for pancreatic stone protein in different age groups |
title_full_unstemmed | Normal values for pancreatic stone protein in different age groups |
title_short | Normal values for pancreatic stone protein in different age groups |
title_sort | normal values for pancreatic stone protein in different age groups |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654823/ https://www.ncbi.nlm.nih.gov/pubmed/26588901 http://dx.doi.org/10.1186/s12871-015-0149-y |
work_keys_str_mv | AT schlapbachluregnj normalvaluesforpancreaticstoneproteinindifferentagegroups AT giannonieric normalvaluesforpancreaticstoneproteinindifferentagegroups AT wellmannsven normalvaluesforpancreaticstoneproteinindifferentagegroups AT stockermartin normalvaluesforpancreaticstoneproteinindifferentagegroups AT ammannrolanda normalvaluesforpancreaticstoneproteinindifferentagegroups AT grafrolf normalvaluesforpancreaticstoneproteinindifferentagegroups |