Cargando…
Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis
BACKGROUND: The role of 18-fluorodeoxyglucose positron emission tomography CT ((18)FDG PET/CT), as a prognostic factor for survival in colorectal cancer patients with liver metastases, is still controversial. We sought to perform a meta-analysis of the literature to address this issue. METHODS: A sy...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654916/ https://www.ncbi.nlm.nih.gov/pubmed/26589835 http://dx.doi.org/10.1186/s40644-015-0055-z |
_version_ | 1782402125726220288 |
---|---|
author | Xia, Qian Liu, Jianjun Wu, Cheng Song, Shaoli Tong, Linjun Huang, Gang Feng, Yuanbo Jiang, Yansheng Liu, Yewei Yin, Ting Ni, Yicheng |
author_facet | Xia, Qian Liu, Jianjun Wu, Cheng Song, Shaoli Tong, Linjun Huang, Gang Feng, Yuanbo Jiang, Yansheng Liu, Yewei Yin, Ting Ni, Yicheng |
author_sort | Xia, Qian |
collection | PubMed |
description | BACKGROUND: The role of 18-fluorodeoxyglucose positron emission tomography CT ((18)FDG PET/CT), as a prognostic factor for survival in colorectal cancer patients with liver metastases, is still controversial. We sought to perform a meta-analysis of the literature to address this issue. METHODS: A systematic literature search was performed to identify the studies that associated (18)FDG PET/CT to clinical survival outcomes of patients with liver metastases. Methodological qualities of the included studies were also assessed. The summarized hazard ratio (HR) was estimated by using fixed- or random-effect model according to heterogeneity between trails. RESULTS: By analyzing a total of 867 patients from 15 studies, we found that PET/CT for metabolic response to the therapy was capable of predicting event-free survival (EFS) and overall survival (OS) with statistical significance, and the HR was 0.45 (95 % confidence interval [CI], 0.26–0.78) and 0.36 (95 % CI, 0.18–0.71), respectively. Furthermore, pre-treatment (18)FDG PET/CT with high standardized uptake value (SUV) was also significantly associated with poorer OS HR, 1.24; (95 % CI, 1.06–1.45). However, we did not find a statistically significant effect of post-treatment SUV for predicting OS HR, 1.68; (95 % CI, 0.63–4.52). CONCLUSIONS: The present meta-analysis confirms that (18)FDG PET/CT is a useful tool to help predict survival outcomes in patients with liver metastases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40644-015-0055-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4654916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46549162015-11-22 Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis Xia, Qian Liu, Jianjun Wu, Cheng Song, Shaoli Tong, Linjun Huang, Gang Feng, Yuanbo Jiang, Yansheng Liu, Yewei Yin, Ting Ni, Yicheng Cancer Imaging Research Article BACKGROUND: The role of 18-fluorodeoxyglucose positron emission tomography CT ((18)FDG PET/CT), as a prognostic factor for survival in colorectal cancer patients with liver metastases, is still controversial. We sought to perform a meta-analysis of the literature to address this issue. METHODS: A systematic literature search was performed to identify the studies that associated (18)FDG PET/CT to clinical survival outcomes of patients with liver metastases. Methodological qualities of the included studies were also assessed. The summarized hazard ratio (HR) was estimated by using fixed- or random-effect model according to heterogeneity between trails. RESULTS: By analyzing a total of 867 patients from 15 studies, we found that PET/CT for metabolic response to the therapy was capable of predicting event-free survival (EFS) and overall survival (OS) with statistical significance, and the HR was 0.45 (95 % confidence interval [CI], 0.26–0.78) and 0.36 (95 % CI, 0.18–0.71), respectively. Furthermore, pre-treatment (18)FDG PET/CT with high standardized uptake value (SUV) was also significantly associated with poorer OS HR, 1.24; (95 % CI, 1.06–1.45). However, we did not find a statistically significant effect of post-treatment SUV for predicting OS HR, 1.68; (95 % CI, 0.63–4.52). CONCLUSIONS: The present meta-analysis confirms that (18)FDG PET/CT is a useful tool to help predict survival outcomes in patients with liver metastases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40644-015-0055-z) contains supplementary material, which is available to authorized users. BioMed Central 2015-11-20 /pmc/articles/PMC4654916/ /pubmed/26589835 http://dx.doi.org/10.1186/s40644-015-0055-z Text en © Xia et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Xia, Qian Liu, Jianjun Wu, Cheng Song, Shaoli Tong, Linjun Huang, Gang Feng, Yuanbo Jiang, Yansheng Liu, Yewei Yin, Ting Ni, Yicheng Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title | Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title_full | Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title_fullStr | Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title_full_unstemmed | Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title_short | Prognostic significance of (18)FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis |
title_sort | prognostic significance of (18)fdg pet/ct in colorectal cancer patients with liver metastases: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654916/ https://www.ncbi.nlm.nih.gov/pubmed/26589835 http://dx.doi.org/10.1186/s40644-015-0055-z |
work_keys_str_mv | AT xiaqian prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT liujianjun prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT wucheng prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT songshaoli prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT tonglinjun prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT huanggang prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT fengyuanbo prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT jiangyansheng prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT liuyewei prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT yinting prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis AT niyicheng prognosticsignificanceof18fdgpetctincolorectalcancerpatientswithlivermetastasesametaanalysis |