Cargando…

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Mutations in the PTEN‐induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is activated by mitochondrial depolarisation and phosphorylates serine 65 (Ser(65)) of the ubiquitin ligase Parkin and ubiquitin to stimulate Park...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Yu‐Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean‐Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654935/ https://www.ncbi.nlm.nih.gov/pubmed/26471730 http://dx.doi.org/10.15252/embj.201591593

Ejemplares similares

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
por: Kondapalli, Chandana, et al.
Publicado: (2012)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)
por: Kazlauskaite, Agne, et al.
Publicado: (2014)

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
por: Kumar, Atul, et al.
Publicado: (2017)

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72
por: Vieweg, Sophie, et al.
Publicado: (2020)

PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation
por: Langemeyer, Lars, et al.
Publicado: (2014)

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
por: Kazlauskaite, Agne, et al.
Publicado: (2014)

Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis
por: Luitz, Manuel P., et al.
Publicado: (2016)

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
por: Wachtel, Rudolf, et al.
Publicado: (2018)

RabGEFs are a major determinant for specific Rab membrane targeting
por: Blümer, Julia, et al.
Publicado: (2013)

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations
por: Woodroof, Helen I., et al.
Publicado: (2011)

Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation
por: Savitskiy, Sergey, et al.
Publicado: (2020)

Ubiquitin and Parkinson's disease through the looking glass of genetics
por: Walden, Helen, et al.
Publicado: (2017)

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
por: Du, Jiqing, et al.
Publicado: (2021)

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
por: McWilliams, Thomas G., et al.
Publicado: (2018)

Whole proteome copy number dataset in primary mouse cortical neurons
por: Antico, Odetta, et al.
Publicado: (2023)

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
por: Ernst, Stefan, et al.
Publicado: (2020)

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
por: Steger, Martin, et al.
Publicado: (2016)

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency
por: Flinn, Laura J., et al.
Publicado: (2014)

Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation
por: Pao, Kuan-Chuan, et al.
Publicado: (2016)

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication
por: Rai, Amrita, et al.
Publicado: (2016)

Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
por: Kaspers, Marietta S., et al.
Publicado: (2023)

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a
por: Sanzà, Paolo, et al.
Publicado: (2019)

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells
por: Kakade, Poonam, et al.
Publicado: (2022)

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease
por: Mouton-Liger, Francois, et al.
Publicado: (2017)

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1
por: Barini, Erica, et al.
Publicado: (2018)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44
por: Malik, Nazma, et al.
Publicado: (2019)

Phosphoproteome Profiling of the Receptor Tyrosine Kinase MuSK Identifies Tyrosine Phosphorylation of Rab GTPases
por: Budayeva, Hanna G., et al.
Publicado: (2022)

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
por: Antico, Odetta, et al.
Publicado: (2021)

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase
por: Muñoz, Ivan M, et al.
Publicado: (2018)

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders
por: Muqit, Miratul M K, et al.
Publicado: (2009)

Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization
por: Osgerby, Laura, et al.
Publicado: (2017)

Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology
por: Schiedel, Matthias, et al.
Publicado: (2020)

Locking GTPases covalently in their functional states
por: Wiegandt, David, et al.
Publicado: (2015)

Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2
por: Vullo, Daniela, et al.
Publicado: (2018)

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
por: Heo, J.-M., et al.
Publicado: (2018)

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies
por: Daub, Herwin, et al.
Publicado: (2020)

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
por: Höpfner, Dorothea, et al.
Publicado: (2020)

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
por: Höpfner, Dorothea, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eaucqpcu6ln3ufdvloipedmikq