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Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics

High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflamma...

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Autores principales: Salazar, Juan, Olivar, Luis Carlos, Ramos, Eduardo, Chávez-Castillo, Mervin, Rojas, Joselyn, Bermúdez, Valmore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655037/
https://www.ncbi.nlm.nih.gov/pubmed/26634153
http://dx.doi.org/10.1155/2015/296417
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author Salazar, Juan
Olivar, Luis Carlos
Ramos, Eduardo
Chávez-Castillo, Mervin
Rojas, Joselyn
Bermúdez, Valmore
author_facet Salazar, Juan
Olivar, Luis Carlos
Ramos, Eduardo
Chávez-Castillo, Mervin
Rojas, Joselyn
Bermúdez, Valmore
author_sort Salazar, Juan
collection PubMed
description High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease.
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spelling pubmed-46550372015-12-02 Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics Salazar, Juan Olivar, Luis Carlos Ramos, Eduardo Chávez-Castillo, Mervin Rojas, Joselyn Bermúdez, Valmore Cholesterol Review Article High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease. Hindawi Publishing Corporation 2015 2015-11-08 /pmc/articles/PMC4655037/ /pubmed/26634153 http://dx.doi.org/10.1155/2015/296417 Text en Copyright © 2015 Juan Salazar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Salazar, Juan
Olivar, Luis Carlos
Ramos, Eduardo
Chávez-Castillo, Mervin
Rojas, Joselyn
Bermúdez, Valmore
Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title_full Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title_fullStr Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title_full_unstemmed Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title_short Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
title_sort dysfunctional high-density lipoprotein: an innovative target for proteomics and lipidomics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655037/
https://www.ncbi.nlm.nih.gov/pubmed/26634153
http://dx.doi.org/10.1155/2015/296417
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