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Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflamma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655037/ https://www.ncbi.nlm.nih.gov/pubmed/26634153 http://dx.doi.org/10.1155/2015/296417 |
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author | Salazar, Juan Olivar, Luis Carlos Ramos, Eduardo Chávez-Castillo, Mervin Rojas, Joselyn Bermúdez, Valmore |
author_facet | Salazar, Juan Olivar, Luis Carlos Ramos, Eduardo Chávez-Castillo, Mervin Rojas, Joselyn Bermúdez, Valmore |
author_sort | Salazar, Juan |
collection | PubMed |
description | High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease. |
format | Online Article Text |
id | pubmed-4655037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46550372015-12-02 Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics Salazar, Juan Olivar, Luis Carlos Ramos, Eduardo Chávez-Castillo, Mervin Rojas, Joselyn Bermúdez, Valmore Cholesterol Review Article High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease. Hindawi Publishing Corporation 2015 2015-11-08 /pmc/articles/PMC4655037/ /pubmed/26634153 http://dx.doi.org/10.1155/2015/296417 Text en Copyright © 2015 Juan Salazar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Salazar, Juan Olivar, Luis Carlos Ramos, Eduardo Chávez-Castillo, Mervin Rojas, Joselyn Bermúdez, Valmore Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title | Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title_full | Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title_fullStr | Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title_full_unstemmed | Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title_short | Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics |
title_sort | dysfunctional high-density lipoprotein: an innovative target for proteomics and lipidomics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655037/ https://www.ncbi.nlm.nih.gov/pubmed/26634153 http://dx.doi.org/10.1155/2015/296417 |
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