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Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo

The Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidem...

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Autor principal: Althaus, Christian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655090/
https://www.ncbi.nlm.nih.gov/pubmed/26618087
http://dx.doi.org/10.7717/peerj.1418
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author Althaus, Christian L.
author_facet Althaus, Christian L.
author_sort Althaus, Christian L.
collection PubMed
description The Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidemics. I fitted an EVD transmission model to previously published data of this outbreak and estimated the basic reproduction number R(0) = 5.2 (95% CI [4.0–6.7]). The model suggests that the net reproduction number R(t) fell below unity 28 days (95% CI [25–34] days) after the onset of symptoms in the index case. This study adds to previous epidemiological descriptions of the 2014 EVD outbreak in DRC, and is consistent with the notion that a rapid implementation of control interventions helped reduce further spread.
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spelling pubmed-46550902015-11-27 Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo Althaus, Christian L. PeerJ Mathematical Biology The Democratic Republic of Congo (DRC) experienced a confined rural outbreak of Ebola virus disease (EVD) with 69 reported cases from July to October 2014. Understanding the transmission dynamics during the outbreak can provide important information for anticipating and controlling future EVD epidemics. I fitted an EVD transmission model to previously published data of this outbreak and estimated the basic reproduction number R(0) = 5.2 (95% CI [4.0–6.7]). The model suggests that the net reproduction number R(t) fell below unity 28 days (95% CI [25–34] days) after the onset of symptoms in the index case. This study adds to previous epidemiological descriptions of the 2014 EVD outbreak in DRC, and is consistent with the notion that a rapid implementation of control interventions helped reduce further spread. PeerJ Inc. 2015-11-19 /pmc/articles/PMC4655090/ /pubmed/26618087 http://dx.doi.org/10.7717/peerj.1418 Text en © 2015 Althaus http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Mathematical Biology
Althaus, Christian L.
Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title_full Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title_fullStr Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title_full_unstemmed Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title_short Rapid drop in the reproduction number during the Ebola outbreak in the Democratic Republic of Congo
title_sort rapid drop in the reproduction number during the ebola outbreak in the democratic republic of congo
topic Mathematical Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655090/
https://www.ncbi.nlm.nih.gov/pubmed/26618087
http://dx.doi.org/10.7717/peerj.1418
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