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Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice

Angiotensin-converting enzyme 2 (ACE2) gene therapy aimed at counteracting pancreatic ACE2 depletion improves glucose regulation in two diabetic mouse models: db/db mice and angiotensin II-infused mice. A disintegrin and metalloproteinase 17 (ADAM17) can cause shedding of ACE2 from the cell membrane...

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Detalles Bibliográficos
Autores principales:	Pedersen, Kim Brint, Chodavarapu, Harshita, Porretta, Constance, Robinson, Leonie K., Lazartigues, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655210/ https://www.ncbi.nlm.nih.gov/pubmed/26441236 http://dx.doi.org/10.1210/en.2015-1556

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