Determining the IC(50) Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver

Vorozole and letrozole are third-generation aromatase (cytochrome P450 19A1) inhibitors. [(11)C]-Vorozole can be used as a radiotracer for aromatase in living animals but when administered by IV, it collects in the liver. Pretreatment with letrozole does not affect the binding of vorozole in the liv...

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Detalles Bibliográficos
Autores principales: Raymond, Lendelle, Rayani, Nikita, Polson, Grace, Sikorski, Kylie, Lian, Ailin, VanAlstine-Parris, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655258/
https://www.ncbi.nlm.nih.gov/pubmed/26635974
http://dx.doi.org/10.1155/2015/321820

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