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Goodness-of-fit test for meta-analysis

Meta-analysis is a very useful tool to combine information from different sources. Fixed effect and random effect models are widely used in meta-analysis. Despite their popularity, they may give us misleading results if the models don’t fit the data but are blindly used. Therefore, like any statisti...

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Detalles Bibliográficos
Autores principales: Chen, Zhongxue, Zhang, Guoyi, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655309/
https://www.ncbi.nlm.nih.gov/pubmed/26592212
http://dx.doi.org/10.1038/srep16983
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author Chen, Zhongxue
Zhang, Guoyi
Li, Jing
author_facet Chen, Zhongxue
Zhang, Guoyi
Li, Jing
author_sort Chen, Zhongxue
collection PubMed
description Meta-analysis is a very useful tool to combine information from different sources. Fixed effect and random effect models are widely used in meta-analysis. Despite their popularity, they may give us misleading results if the models don’t fit the data but are blindly used. Therefore, like any statistical analysis, checking the model fitting is an important step. However, in practice, the goodness-of-fit in meta-analysis is rarely discussed. In this paper, we propose some tests to check the goodness-of-fit for the fixed and random effect models with assumption of normal distributions in meta-analysis. Through simulation study, we show that the proposed tests control type I error rate very well. To demonstrate the usefulness of the proposed tests, we also apply them to some real data sets. Our study shows that the proposed tests are useful tools in checking the goodness-of-fit of the normal models used in meta-analysis.
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spelling pubmed-46553092015-11-27 Goodness-of-fit test for meta-analysis Chen, Zhongxue Zhang, Guoyi Li, Jing Sci Rep Article Meta-analysis is a very useful tool to combine information from different sources. Fixed effect and random effect models are widely used in meta-analysis. Despite their popularity, they may give us misleading results if the models don’t fit the data but are blindly used. Therefore, like any statistical analysis, checking the model fitting is an important step. However, in practice, the goodness-of-fit in meta-analysis is rarely discussed. In this paper, we propose some tests to check the goodness-of-fit for the fixed and random effect models with assumption of normal distributions in meta-analysis. Through simulation study, we show that the proposed tests control type I error rate very well. To demonstrate the usefulness of the proposed tests, we also apply them to some real data sets. Our study shows that the proposed tests are useful tools in checking the goodness-of-fit of the normal models used in meta-analysis. Nature Publishing Group 2015-11-23 /pmc/articles/PMC4655309/ /pubmed/26592212 http://dx.doi.org/10.1038/srep16983 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Zhongxue
Zhang, Guoyi
Li, Jing
Goodness-of-fit test for meta-analysis
title Goodness-of-fit test for meta-analysis
title_full Goodness-of-fit test for meta-analysis
title_fullStr Goodness-of-fit test for meta-analysis
title_full_unstemmed Goodness-of-fit test for meta-analysis
title_short Goodness-of-fit test for meta-analysis
title_sort goodness-of-fit test for meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655309/
https://www.ncbi.nlm.nih.gov/pubmed/26592212
http://dx.doi.org/10.1038/srep16983
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