Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

An efficient targeting delivery technology is needed for functional oligonucleotides to exert their potential effect on the target gene without an adverse effect in vivo. Development of enteral delivery systems for nucleic acids is a major challenge because of their large molecular size and instabil...

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Detalles Bibliográficos
Autores principales: Murakami, Masahiro, Nishina, Kazutaka, Watanabe, Chie, Yoshida-Tanaka, Kie, Piao, Wenying, Kuwahara, Hiroya, Horikiri, Yuji, Miyata, Kanjiro, Nishiyama, Nobuhiro, Kataoka, Kazunori, Yoshida, Masayuki, Mizusawa, Hidehiro, Yokota, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655470/
https://www.ncbi.nlm.nih.gov/pubmed/26593819
http://dx.doi.org/10.1038/srep17035

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