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Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis

BACKGROUND: Cholangiocarcinoma (CCA) is a relatively rare cancer worldwide; however, its incidence is extremely high in Asia. Numerous studies reported that serum carbohydrate antigen 19-9 (CA19-9) plays a role in the diagnosis of CCA patients. However, published data are inconclusive. The aim of th...

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Autores principales: Liang, Bin, Zhong, Liansheng, He, Qun, Wang, Shaocheng, Pan, Zhongcheng, Wang, Tianjiao, Zhao, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655615/
https://www.ncbi.nlm.nih.gov/pubmed/26576628
http://dx.doi.org/10.12659/MSM.895040
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author Liang, Bin
Zhong, Liansheng
He, Qun
Wang, Shaocheng
Pan, Zhongcheng
Wang, Tianjiao
Zhao, Yujie
author_facet Liang, Bin
Zhong, Liansheng
He, Qun
Wang, Shaocheng
Pan, Zhongcheng
Wang, Tianjiao
Zhao, Yujie
author_sort Liang, Bin
collection PubMed
description BACKGROUND: Cholangiocarcinoma (CCA) is a relatively rare cancer worldwide; however, its incidence is extremely high in Asia. Numerous studies reported that serum carbohydrate antigen 19-9 (CA19-9) plays a role in the diagnosis of CCA patients. However, published data are inconclusive. The aim of this meta-analysis was to provide a systematic review of the diagnostic performance of CA19-9 for CCA. MATERIAL/METHODS: We searched the public databases including PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases for articles evaluating the diagnostic accuracy of serum CA19-9 to predict CCA. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. RESULTS: A total of 31 articles met the inclusion criteria, including 1,264 patients and 2,039 controls. The pooled SEN, SPE, PLR, NLR, and DOR were 0.72 (95% CI: 0.70–0.75), 0.84 (95% CI: 0.82–0.85), 4.93 (95% CI, 3.67–6.64), 0.35 (95%CI, 0.30–0.41), and 15.10 (95% CI, 10.70–21.32), respectively. The area under SROC curve was 0.8300. The subgroup analyses based on different control type, geographical location, and sample size revealed that the diagnostic accuracy of CA19-9 tends to be same in different control type, but showed low sensitivity in European patients and small size group. CONCLUSIONS: Serum CA19-9 is a useful non-invasive biomarker for CCA detection and may become a clinically useful tool to identify high-risk patients.
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spelling pubmed-46556152015-12-07 Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis Liang, Bin Zhong, Liansheng He, Qun Wang, Shaocheng Pan, Zhongcheng Wang, Tianjiao Zhao, Yujie Med Sci Monit Meta-Analysis BACKGROUND: Cholangiocarcinoma (CCA) is a relatively rare cancer worldwide; however, its incidence is extremely high in Asia. Numerous studies reported that serum carbohydrate antigen 19-9 (CA19-9) plays a role in the diagnosis of CCA patients. However, published data are inconclusive. The aim of this meta-analysis was to provide a systematic review of the diagnostic performance of CA19-9 for CCA. MATERIAL/METHODS: We searched the public databases including PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases for articles evaluating the diagnostic accuracy of serum CA19-9 to predict CCA. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. RESULTS: A total of 31 articles met the inclusion criteria, including 1,264 patients and 2,039 controls. The pooled SEN, SPE, PLR, NLR, and DOR were 0.72 (95% CI: 0.70–0.75), 0.84 (95% CI: 0.82–0.85), 4.93 (95% CI, 3.67–6.64), 0.35 (95%CI, 0.30–0.41), and 15.10 (95% CI, 10.70–21.32), respectively. The area under SROC curve was 0.8300. The subgroup analyses based on different control type, geographical location, and sample size revealed that the diagnostic accuracy of CA19-9 tends to be same in different control type, but showed low sensitivity in European patients and small size group. CONCLUSIONS: Serum CA19-9 is a useful non-invasive biomarker for CCA detection and may become a clinically useful tool to identify high-risk patients. International Scientific Literature, Inc. 2015-11-18 /pmc/articles/PMC4655615/ /pubmed/26576628 http://dx.doi.org/10.12659/MSM.895040 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Meta-Analysis
Liang, Bin
Zhong, Liansheng
He, Qun
Wang, Shaocheng
Pan, Zhongcheng
Wang, Tianjiao
Zhao, Yujie
Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title_full Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title_fullStr Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title_full_unstemmed Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title_short Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis
title_sort diagnostic accuracy of serum ca19-9 in patients with cholangiocarcinoma: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655615/
https://www.ncbi.nlm.nih.gov/pubmed/26576628
http://dx.doi.org/10.12659/MSM.895040
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