Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

Aprataxin, aprataxin and PNKP-like factor (APLF) and polynucleotide kinase phosphatase (PNKP) are key DNA-repair proteins with diverse functions but which all contain a homologous forkhead-associated (FHA) domain. Their primary binding targets are casein kinase 2-phosphorylated forms of the XRCC1 an...

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Detalles Bibliográficos
Autores principales: Cherry, Amy L., Nott, Timothy J., Kelly, Geoffrey, Rulten, Stuart L., Caldecott, Keith W., Smerdon, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655838/
https://www.ncbi.nlm.nih.gov/pubmed/26519825
http://dx.doi.org/10.1016/j.dnarep.2015.10.002

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