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Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

To gain entry into the target cell, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) uses its spike (S) protein S2 subunit to fuse with the plasma or endosomal membrane. Previous work identified a peptide derived from the heptad repeat (HR) 2 domain in S2 subunit, HR2P, which potently...

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Detalles Bibliográficos
Autores principales:	Channappanavar, Rudragouda, Lu, Lu, Xia, Shuai, Du, Lanying, Meyerholz, David K., Perlman, Stanley, Jiang, Shibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655857/ https://www.ncbi.nlm.nih.gov/pubmed/26164863 http://dx.doi.org/10.1093/infdis/jiv325

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