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P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

BACKGROUND: P16 DNA methylation is well known to be the most frequent event in cancer development. It has been reported that genetic inactivation of P16 drives cancer growth and metastasis, however, whether P16 DNA methylation is truly a driver in cancer metastasis remains unknown. RESULTS: A P16-sp...

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Detalles Bibliográficos
Autores principales:	Cui, Chenghua, Gan, Ying, Gu, Liankun, Wilson, James, Liu, Zhaojun, Zhang, Baozhen, Deng, Dajun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656189/ https://www.ncbi.nlm.nih.gov/pubmed/26592237 http://dx.doi.org/10.1186/s13059-015-0819-6

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