Cargando…

P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

BACKGROUND: P16 DNA methylation is well known to be the most frequent event in cancer development. It has been reported that genetic inactivation of P16 drives cancer growth and metastasis, however, whether P16 DNA methylation is truly a driver in cancer metastasis remains unknown. RESULTS: A P16-sp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Chenghua, Gan, Ying, Gu, Liankun, Wilson, James, Liu, Zhaojun, Zhang, Baozhen, Deng, Dajun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656189/ https://www.ncbi.nlm.nih.gov/pubmed/26592237 http://dx.doi.org/10.1186/s13059-015-0819-6

Ejemplares similares

P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer
por: Liu, Zhaojun, et al.
Publicado: (2019)

C-terminal in Sp1-like artificial zinc-finger proteins plays crucial roles in determining their DNA binding affinity
por: Zhang, Baozhen, et al.
Publicado: (2013)

Significant impact of amount of PCR input templates on various PCR-based DNA methylation analysis and countermeasure
por: Liu, Zhaojun, et al.
Publicado: (2016)

CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma
por: Qiao, Juanli, et al.
Publicado: (2021)

Directed Evolution of Improved Zinc Finger Methyltransferases
por: Chaikind, Brian, et al.
Publicado: (2014)

SRF promotes gastric cancer metastasis through stromal fibroblasts in an SDF1-CXCR4-dependent manner
por: Qiao, Juanli, et al.
Publicado: (2016)

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells
por: Meister, Glenna E., et al.
Publicado: (2010)

P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
por: Li, Paiyun, et al.
Publicado: (2019)

Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the p16 Locus
por: Li, Qiang, et al.
Publicado: (2010)

miR663a-TTC22V1 axis inhibits colon cancer metastasis
por: Tian, Wei, et al.
Publicado: (2019)

Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice
por: Tian, Yuan, et al.
Publicado: (2022)

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool
por: Sander, Jeffry D., et al.
Publicado: (2010)

Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo
por: Du, Yantao, et al.
Publicado: (2012)

Zinc Finger Readers of Methylated DNA
por: Hudson, Nicholas O., et al.
Publicado: (2018)

Inactivation of respiratory syncytial virus by zinc finger reactive compounds
por: Boukhvalova, Marina S, et al.
Publicado: (2010)

Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool
por: Sander, Jeffry D., et al.
Publicado: (2007)

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays
por: Fu, Fengli, et al.
Publicado: (2009)

A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study
por: Liu, Hongwei, et al.
Publicado: (2018)

Heritable Targeted Inactivation of Myostatin Gene in Yellow Catfish (Pelteobagrus fulvidraco) Using Engineered Zinc Finger Nucleases
por: Dong, Zhangji, et al.
Publicado: (2011)

Design of a zinc finger protein binding a sequence upstream of the A20 gene
por: Wei, Yong, et al.
Publicado: (2008)

P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7
por: Li, Zhuoqi, et al.
Publicado: (2022)

Corrigendum: P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7
por: Li, Zhuoqi, et al.
Publicado: (2022)

Targeted genome engineering via zinc finger nucleases
por: Kim, Seokjoong, et al.
Publicado: (2010)

Zinc Finger Database (ZiFDB) v2.0: a comprehensive database of C(2)H(2) zinc fingers and engineered zinc finger arrays
por: Fu, Fengli, et al.
Publicado: (2013)

Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease
por: Xu, Shuang-yong, et al.
Publicado: (2013)

Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients
por: Zheng, Xiang, et al.
Publicado: (2015)

Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas
por: Xiang, Shengyan, et al.
Publicado: (2010)

Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation
por: Ding, Nan, et al.
Publicado: (2020)

Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1
por: Tian, Wei, et al.
Publicado: (2022)

Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research
por: Kim, Moon-Soo, et al.
Publicado: (2017)

Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1
por: Deng, Junxiao, et al.
Publicado: (2017)

P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study
por: Liu, Hongwei, et al.
Publicado: (2015)

Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
por: Wilson, Kimberly A, et al.
Publicado: (2013)

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions
por: Vercruysse, Thomas, et al.
Publicado: (2012)

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
por: Gersbach, Charles A., et al.
Publicado: (2011)

Sequence-specific recognition of methylated DNA by human zinc-finger proteins
por: Sasai, Nobuhiro, et al.
Publicado: (2010)

Bone Marrow-Derived Cells May Not Be the Original Cells for Carcinogen-Induced Mouse Gastrointestinal Carcinomas
por: Yang, Chen, et al.
Publicado: (2013)

Sensory Organ Remodeling in Caenorhabditis elegans Requires the Zinc-Finger Protein ZTF-16
por: Procko, Carl, et al.
Publicado: (2012)

High frequency modification of plant genes using engineered zinc finger nucleases
por: Townsend, Jeffrey A., et al.
Publicado: (2009)

Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases
por: Perez-Pinera, Pablo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n0bfpipk8ji973dpr2ab605kpb