The imaging conundrum of hepatic lymphoma revisited

ABSTRACT: The imaging manifestations of hepatic lymphoma, both in its primary and secondary form, are extremely variable and overlap with a number of other more common hepatic diseases. However, in the appropriate clinical context, combining the imaging and laboratory features can aid in making the correct diagnosis. Since the management and prognosis of lymphomas are significantly different from other malignancies, early diagnosis and prompt commencement of therapy is of paramount importance. The various morphological appearances of hepatic lymphoma on imaging have been described here along with their possible differentials. TEACHING POINTS: • Primary hepatic lymphoma is extremely rare. • Secondary liver involvement occurs in 50 % of patients with non-Hodgkin lymphoma. • The imaging manifestations of hepatic lymphoma are largely non-specific. • Some imaging features may be helpful in the appropriate clinical setting. • Management and prognosis of lymphoma is significantly different from other malignancies.