Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)

(S)-(Hydroxymethyl)glutamic acid was successfully synthesized in total 12 % yield over eight steps from tris(hydroxymethyl)aminomethane hydrochloride (Tris·HCl), employing lipase TL-induced enantioselective acetylation of a prochiral 1,3-diol as the key step. ELECTRONIC SUPPLEMENTARY MATERIAL: The o...

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Detalles Bibliográficos
Autores principales: Yoshioka, Hiromasa, Oikawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656251/
https://www.ncbi.nlm.nih.gov/pubmed/26636014
http://dx.doi.org/10.1186/s40064-015-1503-8
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author Yoshioka, Hiromasa
Oikawa, Masato
author_facet Yoshioka, Hiromasa
Oikawa, Masato
author_sort Yoshioka, Hiromasa
collection PubMed
description (S)-(Hydroxymethyl)glutamic acid was successfully synthesized in total 12 % yield over eight steps from tris(hydroxymethyl)aminomethane hydrochloride (Tris·HCl), employing lipase TL-induced enantioselective acetylation of a prochiral 1,3-diol as the key step. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-015-1503-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-46562512015-12-03 Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG) Yoshioka, Hiromasa Oikawa, Masato Springerplus Research (S)-(Hydroxymethyl)glutamic acid was successfully synthesized in total 12 % yield over eight steps from tris(hydroxymethyl)aminomethane hydrochloride (Tris·HCl), employing lipase TL-induced enantioselective acetylation of a prochiral 1,3-diol as the key step. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-015-1503-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2015-11-24 /pmc/articles/PMC4656251/ /pubmed/26636014 http://dx.doi.org/10.1186/s40064-015-1503-8 Text en © Yoshioka and Oikawa. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Yoshioka, Hiromasa
Oikawa, Masato
Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title_full Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title_fullStr Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title_full_unstemmed Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title_short Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)
title_sort studies on lipase-catalyzed asymmetric synthesis of (s)-(hydroxymethyl)glutamic acid (hmg)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656251/
https://www.ncbi.nlm.nih.gov/pubmed/26636014
http://dx.doi.org/10.1186/s40064-015-1503-8
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