Cargando…

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

An updated model of the GABA(A) benzodiazepine receptor pharmacophore of the α5-BzR/GABA(A) subtype has been constructed prompted by the synthesis of subtype selective ligands in light of the recent developments in both ligand synthesis, behavioral studies, and molecular modeling studies of the bind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clayton, Terry, Poe, Michael M., Rallapalli, Sundari, Biawat, Poonam, Savić, Miroslav M., Rowlett, James K., Gallos, George, Emala, Charles W., Kaczorowski, Catherine C., Stafford, Douglas C., Arnold, Leggy A., Cook, James M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657098/ https://www.ncbi.nlm.nih.gov/pubmed/26682068 http://dx.doi.org/10.1155/2015/430248

Ejemplares similares

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor
por: Li, Guanguan, et al.
Publicado: (2020)

Editorial: Benzodiazepine addiction: from lab to street
por: Berro, Lais F., et al.
Publicado: (2023)

α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513
por: Iyer, Sangeetha V., et al.
Publicado: (2011)

Different Benzodiazepines Bind with Distinct Binding Modes to GABA(A) Receptors
por: Elgarf, Alshaimaa A., et al.
Publicado: (2018)

8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA(A) Receptor
por: Golani, Lalit K., et al.
Publicado: (2021)

Predicting benzodiazepine prescriptions: A proof-of-concept machine learning approach
por: Kinney, Kerry L., et al.
Publicado: (2023)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

Benzodiazepine Modulation of GABA(A) Receptors: A Mechanistic Perspective
por: Goldschen-Ohm, Marcel P.
Publicado: (2022)

GABA(A) receptor subtypes and benzodiazepine use, misuse, and abuse
por: Engin, Elif
Publicado: (2023)

Benzodiazepines modulate GABA(A )receptors by reducing a gamma-subunit-mediated inhibition of GABA sensitivity
por: Baburin, Igor, et al.
Publicado: (2009)

Modulating native GABA(A) receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death
por: Kallay, Laura, et al.
Publicado: (2019)

Context Dependent Benzodiazepine Modulation of GABA(A) Receptor Opening Frequency
por: Bianchi, Matt T
Publicado: (2010)

Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment
por: Licata, Stephanie C., et al.
Publicado: (2013)

Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
por: Savić, Miroslav M., et al.
Publicado: (2005)

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype
por: Ralvenius, William T., et al.
Publicado: (2015)

Behavioral Effects of the Benzodiazepine-Positive Allosteric Modulator SH-053-2’F-S-CH(3) in an Immune-Mediated Neurodevelopmental Disruption Model
por: Richetto, Juliet, et al.
Publicado: (2015)

Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site
por: Lüscher, Benjamin P., et al.
Publicado: (2012)

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA(A) Receptors
por: Lian, Jing-Jing, et al.
Publicado: (2020)

The blood-to-plasma ratio and predicted GABA(A)-binding affinity of designer benzodiazepines
por: Manchester, Kieran R., et al.
Publicado: (2022)

Stereospecific Total Synthesis of the Indole Alkaloid Ervincidine. Establishment of the C-6 Hydroxyl Stereochemistry
por: Rallapalli, Sundari K., et al.
Publicado: (2014)

Can We Find Better Bronchodilators to Relieve Asthma Symptoms?
por: Townsend, Elizabeth A., et al.
Publicado: (2012)

A Unified Model of the GABA(A) Receptor Comprising Agonist and Benzodiazepine Binding Sites
por: Bergmann, Rikke, et al.
Publicado: (2013)

Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines
por: Liu, Yan-Mei, et al.
Publicado: (2017)

A high-resolution in vivo atlas of the human brain’s benzodiazepine binding site of GABA(A) receptors
por: Nørgaard, Martin, et al.
Publicado: (2021)

Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising γ1 or γ2 subunits
por: Baburin, I, et al.
Publicado: (2008)

A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABA(A) receptors
por: Goldschen-Ohm, Marcel P., et al.
Publicado: (2014)

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication
por: Wang, Guoying, et al.
Publicado: (2021)

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA(A) receptor in complex with GABA
por: Phulera, Swastik, et al.
Publicado: (2018)

Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images
por: Myers, James FM, et al.
Publicado: (2012)

Physicians’ Perspectives on Prescribing Benzodiazepines for Older Adults: A Qualitative Study
por: Cook, Joan M., et al.
Publicado: (2007)

Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N(4)-Methyltalpinine
por: Rahman, Md Toufiqur, et al.
Publicado: (2022)

Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes
por: Vinkers, Christiaan H., et al.
Publicado: (2011)

Tackling benzodiazepine misuse
por: Hayhoe, Benedict, et al.
Publicado: (2018)

GABA transient sets the susceptibility of mIPSCs to modulation by benzodiazepine receptor agonists in rat hippocampal neurons
por: Mozrzymas, Jerzy W, et al.
Publicado: (2007)

High-Dose Benzodiazepines Positively Modulate GABA(A) Receptors via a Flumazenil-Insensitive Mechanism
por: Wang, Na, et al.
Publicado: (2021)

Effects of α5 GABA(A) receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease
por: Aranđelović, Jovana, et al.
Publicado: (2022)

Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism
por: Lingford-Hughes, Anne, et al.
Publicado: (2016)

Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations
por: Lee, Ji Young, et al.
Publicado: (2019)

Valium without dependence? Individual GABA(A) receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
por: Cheng, Tianze, et al.
Publicado: (2018)

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA(A) Receptor
por: Yabuki, Yasushi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ulvebvsqo347s0rro264neudee