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Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers

The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) disease. It is now understood that LTBI and active TB represent a continuous spectrum of states with different degrees of patho...

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Autores principales: Lyadova, I. V., Panteleev, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657112/
https://www.ncbi.nlm.nih.gov/pubmed/26640327
http://dx.doi.org/10.1155/2015/854507
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author Lyadova, I. V.
Panteleev, A. V.
author_facet Lyadova, I. V.
Panteleev, A. V.
author_sort Lyadova, I. V.
collection PubMed
description The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) disease. It is now understood that LTBI and active TB represent a continuous spectrum of states with different degrees of pathogen “activity,” host pathology, and immune reactivity. Therefore, it is important to differentiate LTBI and active TB and identify active TB stages. CD4(+) T cells play critical role during Mtb infection by mediating protection, contributing to inflammation, and regulating immune response. Th1 and Th17 cells are the main effector CD4(+) T cells during TB. Th1 cells have been shown to contribute to TB protection by secreting IFN-γ and activating antimycobacterial action in macrophages. Th17 induce neutrophilic inflammation, mediate tissue damage, and thus have been implicated in TB pathology. In recent years new findings have accumulated that alter our view on the role of Th1 and Th17 cells during Mtb infection. This review discusses these new results and how they can be implemented for TB diagnosis and monitoring.
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spelling pubmed-46571122015-12-06 Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers Lyadova, I. V. Panteleev, A. V. Mediators Inflamm Review Article The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) disease. It is now understood that LTBI and active TB represent a continuous spectrum of states with different degrees of pathogen “activity,” host pathology, and immune reactivity. Therefore, it is important to differentiate LTBI and active TB and identify active TB stages. CD4(+) T cells play critical role during Mtb infection by mediating protection, contributing to inflammation, and regulating immune response. Th1 and Th17 cells are the main effector CD4(+) T cells during TB. Th1 cells have been shown to contribute to TB protection by secreting IFN-γ and activating antimycobacterial action in macrophages. Th17 induce neutrophilic inflammation, mediate tissue damage, and thus have been implicated in TB pathology. In recent years new findings have accumulated that alter our view on the role of Th1 and Th17 cells during Mtb infection. This review discusses these new results and how they can be implemented for TB diagnosis and monitoring. Hindawi Publishing Corporation 2015 2015-11-10 /pmc/articles/PMC4657112/ /pubmed/26640327 http://dx.doi.org/10.1155/2015/854507 Text en Copyright © 2015 I. V. Lyadova and A. V. Panteleev. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lyadova, I. V.
Panteleev, A. V.
Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title_full Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title_fullStr Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title_full_unstemmed Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title_short Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
title_sort th1 and th17 cells in tuberculosis: protection, pathology, and biomarkers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657112/
https://www.ncbi.nlm.nih.gov/pubmed/26640327
http://dx.doi.org/10.1155/2015/854507
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