Cargando…

TDP-43 is intercellularly transmitted across axon terminals

Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-containing protein and component of pathological intracellular aggregates found in most amyotrophic lateral sclerosis (ALS) patients. TDP-43 oligomers have been postulated to be released and subsequentl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feiler, Marisa S., Strobel, Benjamin, Freischmidt, Axel, Helferich, Anika M., Kappel, Julia, Brewer, Bryson M., Li, Deyu, Thal, Dietmar R., Walther, Paul, Ludolph, Albert C., Danzer, Karin M., Weishaupt, Jochen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657165/ https://www.ncbi.nlm.nih.gov/pubmed/26598621 http://dx.doi.org/10.1083/jcb.201504057

Ejemplares similares

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
por: Freischmidt, Axel, et al.
Publicado: (2013)

Low T-cell reactivity to TDP-43 peptides in ALS
por: Ramachandran, Swetha, et al.
Publicado: (2023)

α-synuclein interacts with SOD1 and promotes its oligomerization
por: Helferich, Anika M., et al.
Publicado: (2015)

Stress induced TDP-43 mobility loss independent of stress granules
por: Streit, Lisa, et al.
Publicado: (2022)

Increased NF-L levels in the TDP-43(G298S) ALS mouse model resemble NF-L levels in ALS patients
por: Buck, Eva, et al.
Publicado: (2022)

Restoring expression of Stathmin-2: a novel strategy to treat TDP-43 proteinopathies
por: Menge, Sonja, et al.
Publicado: (2023)

Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
por: Peled, Sivan, et al.
Publicado: (2017)

Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton
por: Freischmidt, Axel, et al.
Publicado: (2015)

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43(G298S) ALS mouse model
por: Müller, Hans-Peter, et al.
Publicado: (2019)

Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes
por: Tomé, Sandra O., et al.
Publicado: (2020)

TDP-43 pathology is associated with increased tau burdens and seeding
por: Tomé, Sandra O., et al.
Publicado: (2023)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration
por: Chang, Yung-Heng, et al.
Publicado: (2023)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
por: Beel, Sander, et al.
Publicado: (2018)

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43
por: Xu, Ya-Fei, et al.
Publicado: (2013)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

Metals in ALS TDP-43 Pathology
por: Koski, Lassi, et al.
Publicado: (2021)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Huang, Wendi, et al.
Publicado: (2020)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
por: Flores, Brittany N., et al.
Publicado: (2019)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
por: Necarsulmer, Julie C, et al.
Publicado: (2023)

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice
por: Bruno, Clara, et al.
Publicado: (2020)

Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation
por: McCord, Bryony, et al.
Publicado: (2023)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration
por: Foulds, Penelope, et al.
Publicado: (2008)

Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice
por: Silva, Pablo R., et al.
Publicado: (2019)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
por: Ren, Yuting, et al.
Publicado: (2021)

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
por: Xie, Manling, et al.
Publicado: (2021)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
por: Feneberg, Emily, et al.
Publicado: (2021)

Telomere shortening leads to earlier age of onset in ALS mice
por: Linkus, Birgit, et al.
Publicado: (2016)

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo()
por: Tripathi, Vineeta Bhasker, et al.
Publicado: (2014)

Molecular Neuropathology of TDP-43 Proteinopathies
por: Neumann, Manuela
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jfn4srjl8i9iuqoi4olovvcole