Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

Glycoproteins and non-glycoproteins possessing unfolded/misfolded parts in their luminal regions are cleared from the endoplasmic reticulum (ER) by ER-associated degradation (ERAD)-L with distinct mechanisms. Two-step mannose trimming from Man(9)GlcNAc(2) is crucial in the ERAD-L of glycoproteins. W...

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Detalles Bibliográficos
Autores principales: Ninagawa, Satoshi, Okada, Tetsuya, Sumitomo, Yoshiki, Horimoto, Satoshi, Sugimoto, Takehiro, Ishikawa, Tokiro, Takeda, Shunichi, Yamamoto, Takashi, Suzuki, Tadashi, Kamiya, Yukiko, Kato, Koichi, Mori, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657166/
https://www.ncbi.nlm.nih.gov/pubmed/26572623
http://dx.doi.org/10.1083/jcb.201504109

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