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The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells
The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains unclear. Here, by exploiting a...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657167/ https://www.ncbi.nlm.nih.gov/pubmed/26598619 http://dx.doi.org/10.1083/jcb.201505037 |