Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell

In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the prolif...

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Detalles Bibliográficos
Autores principales: Faraldo, Marisa M., Glukhova, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657175/
https://www.ncbi.nlm.nih.gov/pubmed/26598611
http://dx.doi.org/10.1083/jcb.201510104
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author Faraldo, Marisa M.
Glukhova, Marina A.
author_facet Faraldo, Marisa M.
Glukhova, Marina A.
author_sort Faraldo, Marisa M.
collection PubMed
description In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny.
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spelling pubmed-46571752016-05-23 Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell Faraldo, Marisa M. Glukhova, Marina A. J Cell Biol Reviews In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny. The Rockefeller University Press 2015-11-23 /pmc/articles/PMC4657175/ /pubmed/26598611 http://dx.doi.org/10.1083/jcb.201510104 Text en © 2015 Faraldo and Glukhova This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Faraldo, Marisa M.
Glukhova, Marina A.
Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title_full Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title_fullStr Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title_full_unstemmed Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title_short Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
title_sort regulating the regulator: numb acts upstream of p53 to control mammary stem and progenitor cell
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657175/
https://www.ncbi.nlm.nih.gov/pubmed/26598611
http://dx.doi.org/10.1083/jcb.201510104
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