The interactome challenge

The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an e...

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Detalles Bibliográficos
Autores principales: Aitchison, John D., Rout, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657177/
https://www.ncbi.nlm.nih.gov/pubmed/26572620
http://dx.doi.org/10.1083/jcb.201510108
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author Aitchison, John D.
Rout, Michael P.
author_facet Aitchison, John D.
Rout, Michael P.
author_sort Aitchison, John D.
collection PubMed
description The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beginning to be met.
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spelling pubmed-46571772016-05-23 The interactome challenge Aitchison, John D. Rout, Michael P. J Cell Biol News The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beginning to be met. The Rockefeller University Press 2015-11-23 /pmc/articles/PMC4657177/ /pubmed/26572620 http://dx.doi.org/10.1083/jcb.201510108 Text en © 2015 Rout and Aitchison This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle News
Aitchison, John D.
Rout, Michael P.
The interactome challenge
title The interactome challenge
title_full The interactome challenge
title_fullStr The interactome challenge
title_full_unstemmed The interactome challenge
title_short The interactome challenge
title_sort interactome challenge
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657177/
https://www.ncbi.nlm.nih.gov/pubmed/26572620
http://dx.doi.org/10.1083/jcb.201510108
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