Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes

BACKGROUND: Phagocytosis activity of peripheral blood leukocytes in smokers or chronic obstructive pulmonary disease patients was found to be controversial and dependent on the phagocytic stimulus. RESULTS: We demonstrated that long-term exposure to cigarette smoke in mice clearly suppressed the pha...

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Autores principales: Tschernig, Thomas, Rabung, Andrea, Voss, Meike, Meier, Carola, Bals, Robert, Beisswenger, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657193/
https://www.ncbi.nlm.nih.gov/pubmed/26597815
http://dx.doi.org/10.1186/s13104-015-1706-7
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author Tschernig, Thomas
Rabung, Andrea
Voss, Meike
Meier, Carola
Bals, Robert
Beisswenger, Christoph
author_facet Tschernig, Thomas
Rabung, Andrea
Voss, Meike
Meier, Carola
Bals, Robert
Beisswenger, Christoph
author_sort Tschernig, Thomas
collection PubMed
description BACKGROUND: Phagocytosis activity of peripheral blood leukocytes in smokers or chronic obstructive pulmonary disease patients was found to be controversial and dependent on the phagocytic stimulus. RESULTS: We demonstrated that long-term exposure to cigarette smoke in mice clearly suppressed the phagocytosis of granulocytes and monocytes from peripheral blood. CONCLUSIONS: Impaired phagocytosis activity of peripheral blood leukocytes may have a systemic effect and potentially contribute to smoking-associated diseases such as pneumonia and lung cancer.
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spelling pubmed-46571932015-11-25 Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes Tschernig, Thomas Rabung, Andrea Voss, Meike Meier, Carola Bals, Robert Beisswenger, Christoph BMC Res Notes Short Report BACKGROUND: Phagocytosis activity of peripheral blood leukocytes in smokers or chronic obstructive pulmonary disease patients was found to be controversial and dependent on the phagocytic stimulus. RESULTS: We demonstrated that long-term exposure to cigarette smoke in mice clearly suppressed the phagocytosis of granulocytes and monocytes from peripheral blood. CONCLUSIONS: Impaired phagocytosis activity of peripheral blood leukocytes may have a systemic effect and potentially contribute to smoking-associated diseases such as pneumonia and lung cancer. BioMed Central 2015-11-23 /pmc/articles/PMC4657193/ /pubmed/26597815 http://dx.doi.org/10.1186/s13104-015-1706-7 Text en © Tschernig et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Tschernig, Thomas
Rabung, Andrea
Voss, Meike
Meier, Carola
Bals, Robert
Beisswenger, Christoph
Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title_full Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title_fullStr Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title_full_unstemmed Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title_short Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
title_sort chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657193/
https://www.ncbi.nlm.nih.gov/pubmed/26597815
http://dx.doi.org/10.1186/s13104-015-1706-7
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