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Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer

BACKGROUND: The objective of this study was to investigate the safety and long-term clinical effect of intraperitoneal implantation of sustained-release 5-fluorouracil in patients with advanced colorectal cancer during radical resection. METHODS: A total of 202 patients with advanced colorectal canc...

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Autores principales: Yuan, Hang, Zheng, Bo’an, Tu, Shiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657249/
https://www.ncbi.nlm.nih.gov/pubmed/26596801
http://dx.doi.org/10.1186/s12957-015-0737-9
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author Yuan, Hang
Zheng, Bo’an
Tu, Shiliang
author_facet Yuan, Hang
Zheng, Bo’an
Tu, Shiliang
author_sort Yuan, Hang
collection PubMed
description BACKGROUND: The objective of this study was to investigate the safety and long-term clinical effect of intraperitoneal implantation of sustained-release 5-fluorouracil in patients with advanced colorectal cancer during radical resection. METHODS: A total of 202 patients with advanced colorectal cancer undergoing radical operations were randomly divided into an experimental group (98 cases, intraoperative intraperitoneal implantation of sustained-release 5-fluorouracil 600 mg as local chemotherapy) and a control group (104 cases, without local chemotherapy). The clinical data of the two groups was compared including toxicity, complications, local recurrence rate, distant metastasis, disease-free survival, and 1-, 3-, and 5-year survival rates. RESULTS: Both groups of patients were followed up for more than 5 years, the longest follow-up time was 7.5 years. Bone marrow suppression, hepato-renal function, postoperative anastomotic leakage, pelvic effusion, incision infection, the incidence of intestinal obstruction, venting time, and hospital stay after operation (days) between two groups had no statistical significant difference. Locoregional recurrence and liver metastasis rate were decreased significantly in experimental group (P = 0.04 and 0.04). Extensive peritoneal metastasis and other organ metastasis rates had no significant difference between two groups. In the experimental group, 1-, 3-, and 5-year survival rates were higher than in the control group (95.92 vs 87.50 %, 77.55 vs 64.42 %, and 56.12 vs 40.38 %), which had significant difference. Disease-free survival (DFS) of the experimental group was higher than that of the control group (χ(2) = 5.00, P = 0.025). CONCLUSIONS: Intraperitoneal implantation of sustained-release 5-fluorouracil is safe for advanced colorectal cancer during radical resection, which can reduce locoregional recurrence rate and liver metastasis rate. The long-term efficacy was reliable, and long-term survival and disease-free survival rate can be improved.
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spelling pubmed-46572492015-11-25 Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer Yuan, Hang Zheng, Bo’an Tu, Shiliang World J Surg Oncol Research BACKGROUND: The objective of this study was to investigate the safety and long-term clinical effect of intraperitoneal implantation of sustained-release 5-fluorouracil in patients with advanced colorectal cancer during radical resection. METHODS: A total of 202 patients with advanced colorectal cancer undergoing radical operations were randomly divided into an experimental group (98 cases, intraoperative intraperitoneal implantation of sustained-release 5-fluorouracil 600 mg as local chemotherapy) and a control group (104 cases, without local chemotherapy). The clinical data of the two groups was compared including toxicity, complications, local recurrence rate, distant metastasis, disease-free survival, and 1-, 3-, and 5-year survival rates. RESULTS: Both groups of patients were followed up for more than 5 years, the longest follow-up time was 7.5 years. Bone marrow suppression, hepato-renal function, postoperative anastomotic leakage, pelvic effusion, incision infection, the incidence of intestinal obstruction, venting time, and hospital stay after operation (days) between two groups had no statistical significant difference. Locoregional recurrence and liver metastasis rate were decreased significantly in experimental group (P = 0.04 and 0.04). Extensive peritoneal metastasis and other organ metastasis rates had no significant difference between two groups. In the experimental group, 1-, 3-, and 5-year survival rates were higher than in the control group (95.92 vs 87.50 %, 77.55 vs 64.42 %, and 56.12 vs 40.38 %), which had significant difference. Disease-free survival (DFS) of the experimental group was higher than that of the control group (χ(2) = 5.00, P = 0.025). CONCLUSIONS: Intraperitoneal implantation of sustained-release 5-fluorouracil is safe for advanced colorectal cancer during radical resection, which can reduce locoregional recurrence rate and liver metastasis rate. The long-term efficacy was reliable, and long-term survival and disease-free survival rate can be improved. BioMed Central 2015-11-24 /pmc/articles/PMC4657249/ /pubmed/26596801 http://dx.doi.org/10.1186/s12957-015-0737-9 Text en © Yuan et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yuan, Hang
Zheng, Bo’an
Tu, Shiliang
Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title_full Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title_fullStr Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title_full_unstemmed Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title_short Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
title_sort clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657249/
https://www.ncbi.nlm.nih.gov/pubmed/26596801
http://dx.doi.org/10.1186/s12957-015-0737-9
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