Annotation of pseudogenic gene segments by massively parallel sequencing of rearranged lymphocyte receptor loci

BACKGROUND: The adaptive immune system generates a remarkable range of antigen-specific T-cell receptors (TCRs), allowing the recognition of a diverse set of antigens. Most of this diversity is encoded in the complementarity determining region 3 (CDR3) of the β chain of the αβ TCR, which is generate...

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Detalles Bibliográficos
Autores principales: Dean, Jared, Emerson, Ryan O., Vignali, Marissa, Sherwood, Anna M., Rieder, Mark J., Carlson, Christopher S., Robins, Harlan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657264/
https://www.ncbi.nlm.nih.gov/pubmed/26596423
http://dx.doi.org/10.1186/s13073-015-0238-z

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