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Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia

BACKGROUND: Adult T-cell leukemia (ATL) is a CD4(+) T-cell neoplasm with a poor prognosis. A previous study has shown that there is a strong correlation between the secreted matricellular protein osteopontin (OPN) level and disease severity in ATL patients. Here, we investigated the role of OPN in A...

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Detalles Bibliográficos
Autores principales:	Maeda, Naoyoshi, Ohashi, Takashi, Chagan-Yasutan, Haorile, Hattori, Toshio, Takahashi, Yayoi, Harigae, Hideo, Hasegawa, Hiroo, Yamada, Yasuaki, Fujii, Masahiro, Maenaka, Katsumi, Uede, Toshimitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657376/ https://www.ncbi.nlm.nih.gov/pubmed/26597716 http://dx.doi.org/10.1186/s12977-015-0225-x

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