PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative motor neuron disorder. Genetic studies have linked mutation of the gene SOD1 to ALS pathology as well as several other pathological processes including modulation of glutamatergic function and inflammatory processes....

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Detalles Bibliográficos
Autores principales: Brownell, Anna-Liisa, Kuruppu, Darshini, Kil, Kun-Eek, Jokivarsi, Kimmo, Poutiainen, Pekka, Zhu, Aijun, Maxwell, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657381/
https://www.ncbi.nlm.nih.gov/pubmed/26597638
http://dx.doi.org/10.1186/s12974-015-0439-9

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