T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters

T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide–MHC (pMHC) ligands, but there is little direct information on the minimum time required for processing elementar...

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Detalles Bibliográficos
Autores principales: Brodovitch, Alexandre, Shenderov, Eugene, Cerundolo, Vincenzo, Bongrand, Pierre, Pierres, Anne, van der Merwe, Philip Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Cellular Immune Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657482/
https://www.ncbi.nlm.nih.gov/pubmed/25782169
http://dx.doi.org/10.1002/eji.201445214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657482/
https://www.ncbi.nlm.nih.gov/pubmed/25782169
http://dx.doi.org/10.1002/eji.201445214

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