Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes

Reactive oxygen species (ROS) play prominent roles in numerous biological systems. While classically expressed by neutrophils and macrophages, CD4 T cells also express NADPH oxidase (NOX), the superoxide-generating multisubunit enzyme. Our laboratory recently demonstrated that superoxide-deficient n...

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Detalles Bibliográficos
Autores principales: Padgett, Lindsey E., Anderson, Brian, Liu, Chao, Ganini, Douglas, Mason, Ronald P., Piganelli, Jon D., Mathews, Clayton E., Tse, Hubert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657579/
https://www.ncbi.nlm.nih.gov/pubmed/26269022
http://dx.doi.org/10.2337/db15-0546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657579/
https://www.ncbi.nlm.nih.gov/pubmed/26269022
http://dx.doi.org/10.2337/db15-0546

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