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Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes
Reactive oxygen species (ROS) play prominent roles in numerous biological systems. While classically expressed by neutrophils and macrophages, CD4 T cells also express NADPH oxidase (NOX), the superoxide-generating multisubunit enzyme. Our laboratory recently demonstrated that superoxide-deficient n...
Autores principales: | Padgett, Lindsey E., Anderson, Brian, Liu, Chao, Ganini, Douglas, Mason, Ronald P., Piganelli, Jon D., Mathews, Clayton E., Tse, Hubert M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657579/ https://www.ncbi.nlm.nih.gov/pubmed/26269022 http://dx.doi.org/10.2337/db15-0546 |
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