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Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes

Apoptosis is the major cause of death of insulin-producing β-cells in type 1 diabetes mellitus (T1DM). Klotho is a recently discovered antiaging gene. We found that the Klotho gene is expressed in pancreatic β-cells. Interestingly, halplodeficiency of Klotho (KL(+/−)) exacerbated streptozotocin (STZ...

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Detalles Bibliográficos
Autores principales:	Lin, Yi, Sun, Zhongjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Pharmacology and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657580/ https://www.ncbi.nlm.nih.gov/pubmed/26340932 http://dx.doi.org/10.2337/db15-0066

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