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Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis
The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lun...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657794/ https://www.ncbi.nlm.nih.gov/pubmed/26640383 http://dx.doi.org/10.2147/OTT.S94300 |
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author | Zhao, Qing-Tao Guo, Tao Wang, Hui-En Zhang, Xiao-Peng Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen |
author_facet | Zhao, Qing-Tao Guo, Tao Wang, Hui-En Zhang, Xiao-Peng Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen |
author_sort | Zhao, Qing-Tao |
collection | PubMed |
description | The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. |
format | Online Article Text |
id | pubmed-4657794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46577942015-12-04 Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis Zhao, Qing-Tao Guo, Tao Wang, Hui-En Zhang, Xiao-Peng Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen Onco Targets Ther Original Research The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46–0.87), SPE =0.96 (95% CI: 0.91–0.99), PLR 20.01 (95% CI: 6.96–57.52), NLR 0.31 (95% CI: 0.15–0.64), and DOR 65.11 (95% CI: 13.10–323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94–0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future. Dove Medical Press 2015-11-19 /pmc/articles/PMC4657794/ /pubmed/26640383 http://dx.doi.org/10.2147/OTT.S94300 Text en © 2015 Zhao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhao, Qing-Tao Guo, Tao Wang, Hui-En Zhang, Xiao-Peng Zhang, Hua Wang, Zhi-Kang Yuan, Zheng Duan, Guo-Chen Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title | Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_full | Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_fullStr | Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_full_unstemmed | Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_short | Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis |
title_sort | diagnostic value of shox2 dna methylation in lung cancer: a meta-analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657794/ https://www.ncbi.nlm.nih.gov/pubmed/26640383 http://dx.doi.org/10.2147/OTT.S94300 |
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