Cargando…
Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig
Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-pe...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657906/ https://www.ncbi.nlm.nih.gov/pubmed/26599238 http://dx.doi.org/10.1371/journal.pone.0143606 |
_version_ | 1782402434130247680 |
---|---|
author | Giese, Arnaud P. J. Guarnaschelli, Jess G. Ward, Jonette A. Choo, Daniel I. Riazuddin, Saima Ahmed, Zubair M. |
author_facet | Giese, Arnaud P. J. Guarnaschelli, Jess G. Ward, Jonette A. Choo, Daniel I. Riazuddin, Saima Ahmed, Zubair M. |
author_sort | Giese, Arnaud P. J. |
collection | PubMed |
description | Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group. ABR thresholds of guinea pigs that received an intra-peritoneal dose of PrC-210 were significantly better compared to the non-treated, control animals at one week post-radiation. Morphologic analysis of the inner ear revealed significant inflammation and degeneration of the spiral ganglion in the irradiated animals not treated with PrC-210. In contrast, when treated with PrC-210 the radiation effect and injury to the spiral ganglion was significantly alleviated. PrC-210 had no apparent cytotoxic effect in vivo and did not affect the morphology or count of cochlear hair cells. These findings suggest that aminothiol PrC-210 attenuated radiation-induced cochlea damage for at least one week and protected hearing. |
format | Online Article Text |
id | pubmed-4657906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46579062015-12-02 Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig Giese, Arnaud P. J. Guarnaschelli, Jess G. Ward, Jonette A. Choo, Daniel I. Riazuddin, Saima Ahmed, Zubair M. PLoS One Research Article Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group. ABR thresholds of guinea pigs that received an intra-peritoneal dose of PrC-210 were significantly better compared to the non-treated, control animals at one week post-radiation. Morphologic analysis of the inner ear revealed significant inflammation and degeneration of the spiral ganglion in the irradiated animals not treated with PrC-210. In contrast, when treated with PrC-210 the radiation effect and injury to the spiral ganglion was significantly alleviated. PrC-210 had no apparent cytotoxic effect in vivo and did not affect the morphology or count of cochlear hair cells. These findings suggest that aminothiol PrC-210 attenuated radiation-induced cochlea damage for at least one week and protected hearing. Public Library of Science 2015-11-23 /pmc/articles/PMC4657906/ /pubmed/26599238 http://dx.doi.org/10.1371/journal.pone.0143606 Text en © 2015 Giese et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Giese, Arnaud P. J. Guarnaschelli, Jess G. Ward, Jonette A. Choo, Daniel I. Riazuddin, Saima Ahmed, Zubair M. Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title_full | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title_fullStr | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title_full_unstemmed | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title_short | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig |
title_sort | radioprotective effect of aminothiol prc-210 on irradiated inner ear of guinea pig |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657906/ https://www.ncbi.nlm.nih.gov/pubmed/26599238 http://dx.doi.org/10.1371/journal.pone.0143606 |
work_keys_str_mv | AT giesearnaudpj radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT guarnaschellijessg radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT wardjonettea radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT choodanieli radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT riazuddinsaima radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT ahmedzubairm radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig |