Multi-Parametric MRI and Texture Analysis to Visualize Spatial Histologic Heterogeneity and Tumor Extent in Glioblastoma

BACKGROUND: Genetic profiling represents the future of neuro-oncology but suffers from inadequate biopsies in heterogeneous tumors like Glioblastoma (GBM). Contrast-enhanced MRI (CE-MRI) targets enhancing core (ENH) but yields adequate tumor in only ~60% of cases. Further, CE-MRI poorly localizes in...

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Detalles Bibliográficos
Autores principales: Hu, Leland S., Ning, Shuluo, Eschbacher, Jennifer M., Gaw, Nathan, Dueck, Amylou C., Smith, Kris A., Nakaji, Peter, Plasencia, Jonathan, Ranjbar, Sara, Price, Stephen J., Tran, Nhan, Loftus, Joseph, Jenkins, Robert, O’Neill, Brian P., Elmquist, William, Baxter, Leslie C., Gao, Fei, Frakes, David, Karis, John P., Zwart, Christine, Swanson, Kristin R., Sarkaria, Jann, Wu, Teresa, Mitchell, J. Ross, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658019/
https://www.ncbi.nlm.nih.gov/pubmed/26599106
http://dx.doi.org/10.1371/journal.pone.0141506

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