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Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the associ...

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Autores principales: Sarfo, Fred Stephen, Eberhardt, Kirsten Alexandra, Dompreh, Albert, Kuffour, Edmund Osei, Soltau, Mareike, Schachscheider, Marei, Drexler, Jan Felix, Eis-Hübinger, Anna Maria, Häussinger, Dieter, Oteng-Seifah, Emelia Efua, Bedu-Addo, George, Phillips, Richard Odame, Norman, Betty, Burchard, Gerd, Feldt, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658036/
https://www.ncbi.nlm.nih.gov/pubmed/26599971
http://dx.doi.org/10.1371/journal.pone.0143388
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author Sarfo, Fred Stephen
Eberhardt, Kirsten Alexandra
Dompreh, Albert
Kuffour, Edmund Osei
Soltau, Mareike
Schachscheider, Marei
Drexler, Jan Felix
Eis-Hübinger, Anna Maria
Häussinger, Dieter
Oteng-Seifah, Emelia Efua
Bedu-Addo, George
Phillips, Richard Odame
Norman, Betty
Burchard, Gerd
Feldt, Torsten
author_facet Sarfo, Fred Stephen
Eberhardt, Kirsten Alexandra
Dompreh, Albert
Kuffour, Edmund Osei
Soltau, Mareike
Schachscheider, Marei
Drexler, Jan Felix
Eis-Hübinger, Anna Maria
Häussinger, Dieter
Oteng-Seifah, Emelia Efua
Bedu-Addo, George
Phillips, Richard Odame
Norman, Betty
Burchard, Gerd
Feldt, Torsten
author_sort Sarfo, Fred Stephen
collection PubMed
description BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country. METHODS: HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status. RESULTS: The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection. CONCLUSIONS: H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.
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spelling pubmed-46580362015-12-02 Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana Sarfo, Fred Stephen Eberhardt, Kirsten Alexandra Dompreh, Albert Kuffour, Edmund Osei Soltau, Mareike Schachscheider, Marei Drexler, Jan Felix Eis-Hübinger, Anna Maria Häussinger, Dieter Oteng-Seifah, Emelia Efua Bedu-Addo, George Phillips, Richard Odame Norman, Betty Burchard, Gerd Feldt, Torsten PLoS One Research Article BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country. METHODS: HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status. RESULTS: The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection. CONCLUSIONS: H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation. Public Library of Science 2015-11-24 /pmc/articles/PMC4658036/ /pubmed/26599971 http://dx.doi.org/10.1371/journal.pone.0143388 Text en © 2015 Sarfo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sarfo, Fred Stephen
Eberhardt, Kirsten Alexandra
Dompreh, Albert
Kuffour, Edmund Osei
Soltau, Mareike
Schachscheider, Marei
Drexler, Jan Felix
Eis-Hübinger, Anna Maria
Häussinger, Dieter
Oteng-Seifah, Emelia Efua
Bedu-Addo, George
Phillips, Richard Odame
Norman, Betty
Burchard, Gerd
Feldt, Torsten
Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title_full Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title_fullStr Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title_full_unstemmed Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title_short Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
title_sort helicobacter pylori infection is associated with higher cd4 t cell counts and lower hiv-1 viral loads in art-naïve hiv-positive patients in ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658036/
https://www.ncbi.nlm.nih.gov/pubmed/26599971
http://dx.doi.org/10.1371/journal.pone.0143388
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