IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

Interleukin 4-induced gene-1 (IL4I1) was initially described as an early IL-4-inducible gene in B cells. IL4I1 protein can inhibit T cell proliferation by releasing its enzymatic catabolite, H(2)O(2), and this effect is associated with transient down-regulation of T cell CD3 receptor-zeta (TCRζ) exp...

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Detalles Bibliográficos
Autores principales: Yue, Yinpu, Huang, Wei, Liang, Jingjing, Guo, Jing, Ji, Jian, Yao, Yunliang, Zheng, Mingzhu, Cai, Zhijian, Lu, Linrong, Wang, Jianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658051/
https://www.ncbi.nlm.nih.gov/pubmed/26599209
http://dx.doi.org/10.1371/journal.pone.0142979

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