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Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort

BACKGROUND: Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on...

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Autores principales: Kanda, Eiichiro, Muneyuki, Toshitaka, Suwa, Kaname, Nakajima, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658128/
https://www.ncbi.nlm.nih.gov/pubmed/26599331
http://dx.doi.org/10.1371/journal.pone.0143434
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author Kanda, Eiichiro
Muneyuki, Toshitaka
Suwa, Kaname
Nakajima, Kei
author_facet Kanda, Eiichiro
Muneyuki, Toshitaka
Suwa, Kaname
Nakajima, Kei
author_sort Kanda, Eiichiro
collection PubMed
description BACKGROUND: Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender. METHODS: A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics. RESULTS: The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m(2) for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m(2)/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m(2)≤BMI<25 kg/m(2)). A decreasing BMI change (<-2 kg/m(2)/year) was associated with an increasing eGFR change in overweight males (25 kg/m(2)≤BMI). Among underweight females (BMI<18.5 kg/m(2)), decreasing BMI was observed with decreasing eGFR. CONCLUSIONS: These findings suggest that the benefit and risk of weight loss in relation to kidney function differs depending on BMI and weight loss speed, especially in males.
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spelling pubmed-46581282015-12-02 Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort Kanda, Eiichiro Muneyuki, Toshitaka Suwa, Kaname Nakajima, Kei PLoS One Research Article BACKGROUND: Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender. METHODS: A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics. RESULTS: The subjects were stratified into four groups according to BMI. The mean±standard deviations for males and females were, respectively, 40.11±9.49, and 40.3±9.71 years for age and 76.39±17.72 and 71.49±18.4 ml/min/1.73m(2) for eGFR. GAMs showed that a decreasing BMI change (<-1 kg/m(2)/year) was associated with a decreasing eGFR change in males with high normal BMIs (22 kg/m(2)≤BMI<25 kg/m(2)). A decreasing BMI change (<-2 kg/m(2)/year) was associated with an increasing eGFR change in overweight males (25 kg/m(2)≤BMI). Among underweight females (BMI<18.5 kg/m(2)), decreasing BMI was observed with decreasing eGFR. CONCLUSIONS: These findings suggest that the benefit and risk of weight loss in relation to kidney function differs depending on BMI and weight loss speed, especially in males. Public Library of Science 2015-11-23 /pmc/articles/PMC4658128/ /pubmed/26599331 http://dx.doi.org/10.1371/journal.pone.0143434 Text en © 2015 Kanda et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kanda, Eiichiro
Muneyuki, Toshitaka
Suwa, Kaname
Nakajima, Kei
Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title_full Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title_fullStr Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title_full_unstemmed Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title_short Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort
title_sort effects of weight loss speed on kidney function differ depending on body mass index in nondiabetic healthy people: a prospective cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658128/
https://www.ncbi.nlm.nih.gov/pubmed/26599331
http://dx.doi.org/10.1371/journal.pone.0143434
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