Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster

Insulin/insulin-like growth factor signalling (IIS), acting primarily through the PI3-kinase (PI3K)/AKT kinase signalling cassette, plays key evolutionarily conserved regulatory roles in nutrient homeostasis, growth, ageing and longevity. The dysfunction of this pathway has been linked to several ag...

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Detalles Bibliográficos
Autores principales: Mensah, Lawrence B., Davison, Claire, Fan, Shih-Jung, Morris, John F., Goberdhan, Deborah C. I., Wilson, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658134/
https://www.ncbi.nlm.nih.gov/pubmed/26599788
http://dx.doi.org/10.1371/journal.pone.0143818

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