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Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

The Klotho protein is a β-glucuronidase, and its overexpression is associated with life extension. Its mechanism of action is not fully understood, although it has been recently reported that αKlotho improves synaptic and cognitive functions, and it may also influence a variety of structures and fun...

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Detalles Bibliográficos
Autores principales:	Massó, Anna, Sánchez, Angela, Gimenez-Llort, Lydia, Lizcano, Jose Miguel, Cañete, Manuel, García, Belen, Torres-Lista, Virginia, Puig, Meritxell, Bosch, Assumpció, Chillon, Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658185/ https://www.ncbi.nlm.nih.gov/pubmed/26599613 http://dx.doi.org/10.1371/journal.pone.0143623

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