Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic β-hairpin peptide

HPLW, a designed VEGF (Vascular Endothelium Growth Factor) receptor-binding peptide, assumes a well folded β-hairpin conformation in water and is able to induce angiogenesis in vivo. In this study, we investigated at atomic resolution the thermal folding/unfolding pathway of HPLW by means of an orig...

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Detalles Bibliográficos
Autores principales: Diana, Donatella, De Rosa, Lucia, Palmieri, Maddalena, Russomanno, Anna, Russo, Luigi, La Rosa, Carmelo, Milardi, Danilo, Colombo, Giorgio, D’Andrea, Luca D., Fattorusso, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658480/
https://www.ncbi.nlm.nih.gov/pubmed/26602442
http://dx.doi.org/10.1038/srep16651

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