GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses

Alum adjuvanticity is still an unknown mechanism despite the frequent use as vaccine adjuvant in humans. Here we show that Alum-induced inflammasome activation in vitro and in vivo is mediated by the G protein-coupled receptor GPRC6A. The Alum-induced humoral response in vivo was independent of the...

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Detalles Bibliográficos
Autores principales: Quandt, Dagmar, Rothe, Kathrin, Baerwald, Christoph, Rossol, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658484/
https://www.ncbi.nlm.nih.gov/pubmed/26602597
http://dx.doi.org/10.1038/srep16719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658484/
https://www.ncbi.nlm.nih.gov/pubmed/26602597
http://dx.doi.org/10.1038/srep16719

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