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GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses
Alum adjuvanticity is still an unknown mechanism despite the frequent use as vaccine adjuvant in humans. Here we show that Alum-induced inflammasome activation in vitro and in vivo is mediated by the G protein-coupled receptor GPRC6A. The Alum-induced humoral response in vivo was independent of the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658484/ https://www.ncbi.nlm.nih.gov/pubmed/26602597 http://dx.doi.org/10.1038/srep16719 |