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An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses

A poliomyelitis outbreak caused by type 1 circulating vaccine-derived polioviruses (cVDPVs) was identified in China in 2004. Six independent cVDPVs (eight isolates) could be grouped into a single cluster with pathways of divergence different from a single cVDPV progenitor, which circulated and evolv...

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Autores principales: Zhang, Yong, Yan, Dongmei, Zhu, Shuangli, Nishimura, Yorihiro, Ye, Xufang, Wang, Dongyan, Jorba, Jaume, Zhu, Hui, An, Hongqiu, Shimizu, Hiroyuki, Kew, Olen, Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658552/
https://www.ncbi.nlm.nih.gov/pubmed/26603565
http://dx.doi.org/10.1038/srep17291
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author Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Nishimura, Yorihiro
Ye, Xufang
Wang, Dongyan
Jorba, Jaume
Zhu, Hui
An, Hongqiu
Shimizu, Hiroyuki
Kew, Olen
Xu, Wenbo
author_facet Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Nishimura, Yorihiro
Ye, Xufang
Wang, Dongyan
Jorba, Jaume
Zhu, Hui
An, Hongqiu
Shimizu, Hiroyuki
Kew, Olen
Xu, Wenbo
author_sort Zhang, Yong
collection PubMed
description A poliomyelitis outbreak caused by type 1 circulating vaccine-derived polioviruses (cVDPVs) was identified in China in 2004. Six independent cVDPVs (eight isolates) could be grouped into a single cluster with pathways of divergence different from a single cVDPV progenitor, which circulated and evolved into both a highly neurovirulent lineage and a less neurovirulent lineage. They were as neurovirulent as the wild type 1 Mahoney strain, recombination was absent, and their nucleotide 480-G was identical to that of the Sabin strain. The Guizhou/China cVDPV strains shared 4 amino acid replacements in the NAg sites: 3 located at the BC loop, which may underlie the aberrant results of the ELISA intratypic differentiation (ITD) test. The complete ORF tree diverged into two main branches from a common ancestral infection estimated to have occurred in about mid-September 2003, nine months before the appearance of the VDPV case, which indicated recently evolved VDPV. Further, recombination with species C enteroviruses may indicate the presence and density of these enteroviruses in the population and prolonged virus circulation in the community. The aforementioned cVDPVs has important implications in the global initiative to eradicate polio: high quality surveillance permitted earliest detection and response.
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spelling pubmed-46585522015-11-30 An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses Zhang, Yong Yan, Dongmei Zhu, Shuangli Nishimura, Yorihiro Ye, Xufang Wang, Dongyan Jorba, Jaume Zhu, Hui An, Hongqiu Shimizu, Hiroyuki Kew, Olen Xu, Wenbo Sci Rep Article A poliomyelitis outbreak caused by type 1 circulating vaccine-derived polioviruses (cVDPVs) was identified in China in 2004. Six independent cVDPVs (eight isolates) could be grouped into a single cluster with pathways of divergence different from a single cVDPV progenitor, which circulated and evolved into both a highly neurovirulent lineage and a less neurovirulent lineage. They were as neurovirulent as the wild type 1 Mahoney strain, recombination was absent, and their nucleotide 480-G was identical to that of the Sabin strain. The Guizhou/China cVDPV strains shared 4 amino acid replacements in the NAg sites: 3 located at the BC loop, which may underlie the aberrant results of the ELISA intratypic differentiation (ITD) test. The complete ORF tree diverged into two main branches from a common ancestral infection estimated to have occurred in about mid-September 2003, nine months before the appearance of the VDPV case, which indicated recently evolved VDPV. Further, recombination with species C enteroviruses may indicate the presence and density of these enteroviruses in the population and prolonged virus circulation in the community. The aforementioned cVDPVs has important implications in the global initiative to eradicate polio: high quality surveillance permitted earliest detection and response. Nature Publishing Group 2015-11-25 /pmc/articles/PMC4658552/ /pubmed/26603565 http://dx.doi.org/10.1038/srep17291 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Nishimura, Yorihiro
Ye, Xufang
Wang, Dongyan
Jorba, Jaume
Zhu, Hui
An, Hongqiu
Shimizu, Hiroyuki
Kew, Olen
Xu, Wenbo
An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title_full An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title_fullStr An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title_full_unstemmed An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title_short An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses
title_sort insight into recombination with enterovirus species c and nucleotide g-480 reversion from the viewpoint of neurovirulence of vaccine-derived polioviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658552/
https://www.ncbi.nlm.nih.gov/pubmed/26603565
http://dx.doi.org/10.1038/srep17291
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