Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa

Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and su...

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Detalles Bibliográficos
Autores principales: Belard, Sabine, Toepfner, Nicole, Capan-Melser, Mesküre, Mombo-Ngoma, Ghyslain, Zoleko-Manego, Rella, Groger, Mirjam, Matsiegui, Pierre-Blaise, Agnandji, Selidji T., Adegnika, Ayôla A., González, Raquel, Kremsner, Peter G., Menendez, Clara, Ramharter, Michael, Berner, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658565/
https://www.ncbi.nlm.nih.gov/pubmed/26603208
http://dx.doi.org/10.1038/srep17281
Descripción
Sumario:Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.

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