A conserved motif flags Acyl Carrier Proteins for β-branching in polyketide synthesis

Type I PKSs often utilise programmed β-branching, via enzymes of an “HMG-CoA synthase (HCS) cassette”, to incorporate various side chains at the second carbon from the terminal carboxylic acid of growing polyketide backbones. We identified a strong sequence motif in Acyl Carrier Proteins (ACPs) wher...

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Detalles Bibliográficos
Autores principales: Haines, Anthony S, Dong, Xu, Song, Zhongshu, Farmer, Rohit, Williams, Christopher, Hothersall, Joanne, Płoskoń, Eliza, Wattana-amorn, Pakorn, Stephens, Elton R., Yamada, Erika, Gurney, Rachel, Takebayashi, Yuiko, Masschelein, Joleen, Cox, Russell J., Lavigne, Rob, Willis, Christine L., Simpson, Thomas J., Crosby, John, Winn, Peter J., Thomas, Christopher M., Crump, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658705/
https://www.ncbi.nlm.nih.gov/pubmed/24056399
http://dx.doi.org/10.1038/nchembio.1342

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