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Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice

BACKGROUND: Mucosal delivery of therapeutic proteins using genetically modified strains of lactic acid bacteria (gmLAB) is being investigated as a new therapeutic strategy. METHODS: We developed a strain of gmLAB, Lactococcus lactis NZ9000 (NZ-HO), which secretes the anti-inflammatory molecule recom...

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Detalles Bibliográficos
Autores principales:	Shigemori, Suguru, Watanabe, Takafumi, Kudoh, Kai, Ihara, Masaki, Nigar, Shireen, Yamamoto, Yoshinari, Suda, Yoshihito, Sato, Takashi, Kitazawa, Haruki, Shimosato, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658813/ https://www.ncbi.nlm.nih.gov/pubmed/26608030 http://dx.doi.org/10.1186/s12934-015-0378-2

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