Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn’s Disease

The ileal lesions of Crohn’s disease (CD) patients are colonized by adherent-invasive Escherichia coli (AIEC) bacteria. These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner. In this study, we investigated different antagonists of FimH, the a...

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Detalles Bibliográficos
Autores principales: Sivignon, Adeline, Yan, Xibo, Alvarez Dorta, Dimitri, Bonnet, Richard, Bouckaert, Julie, Fleury, Etienne, Bernard, Julien, Gouin, Sébastien G., Darfeuille-Michaud, Arlette, Barnich, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659459/
https://www.ncbi.nlm.nih.gov/pubmed/26578673
http://dx.doi.org/10.1128/mBio.01298-15

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