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Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study

In this study, we explored the applicability of using in vitro micronucleus (MN) data from human lymphoblastoid TK6 cells to derive in vivo genotoxicity potency information. Nineteen chemicals covering a broad spectrum of genotoxic modes of action were tested in an in vitro MN test using TK6 cells u...

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Detalles Bibliográficos
Autores principales:	Soeteman-Hernández, Lya G., Fellows, Mick D., Johnson, George E., Slob, Wout
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Benchmark Doses and Micronucleus Test Data
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659532/ https://www.ncbi.nlm.nih.gov/pubmed/26443842 http://dx.doi.org/10.1093/toxsci/kfv189

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