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Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659557/ https://www.ncbi.nlm.nih.gov/pubmed/26605788 http://dx.doi.org/10.1371/journal.pone.0142267 |
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author | Nunes, Marielza Andrade Schöwe, Natalia Mendes Monteiro-Silva, Karla Cristina Baraldi-Tornisielo, Ticiana Souza, Suzzanna Ingryd Gonçalves Balthazar, Janaina Albuquerque, Marilia Silva Caetano, Ariadiny Lima Viel, Tania Araujo Buck, Hudson Sousa |
author_facet | Nunes, Marielza Andrade Schöwe, Natalia Mendes Monteiro-Silva, Karla Cristina Baraldi-Tornisielo, Ticiana Souza, Suzzanna Ingryd Gonçalves Balthazar, Janaina Albuquerque, Marilia Silva Caetano, Ariadiny Lima Viel, Tania Araujo Buck, Hudson Sousa |
author_sort | Nunes, Marielza Andrade |
collection | PubMed |
description | The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (1.2 mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer’s disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained. |
format | Online Article Text |
id | pubmed-4659557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46595572015-12-02 Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease Nunes, Marielza Andrade Schöwe, Natalia Mendes Monteiro-Silva, Karla Cristina Baraldi-Tornisielo, Ticiana Souza, Suzzanna Ingryd Gonçalves Balthazar, Janaina Albuquerque, Marilia Silva Caetano, Ariadiny Lima Viel, Tania Araujo Buck, Hudson Sousa PLoS One Research Article The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (1.2 mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer’s disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained. Public Library of Science 2015-11-25 /pmc/articles/PMC4659557/ /pubmed/26605788 http://dx.doi.org/10.1371/journal.pone.0142267 Text en © 2015 Nunes et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nunes, Marielza Andrade Schöwe, Natalia Mendes Monteiro-Silva, Karla Cristina Baraldi-Tornisielo, Ticiana Souza, Suzzanna Ingryd Gonçalves Balthazar, Janaina Albuquerque, Marilia Silva Caetano, Ariadiny Lima Viel, Tania Araujo Buck, Hudson Sousa Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title_full | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title_fullStr | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title_full_unstemmed | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title_short | Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease |
title_sort | chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of alzheimer's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659557/ https://www.ncbi.nlm.nih.gov/pubmed/26605788 http://dx.doi.org/10.1371/journal.pone.0142267 |
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