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Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the...

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Autores principales: Nunes, Marielza Andrade, Schöwe, Natalia Mendes, Monteiro-Silva, Karla Cristina, Baraldi-Tornisielo, Ticiana, Souza, Suzzanna Ingryd Gonçalves, Balthazar, Janaina, Albuquerque, Marilia Silva, Caetano, Ariadiny Lima, Viel, Tania Araujo, Buck, Hudson Sousa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659557/
https://www.ncbi.nlm.nih.gov/pubmed/26605788
http://dx.doi.org/10.1371/journal.pone.0142267
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author Nunes, Marielza Andrade
Schöwe, Natalia Mendes
Monteiro-Silva, Karla Cristina
Baraldi-Tornisielo, Ticiana
Souza, Suzzanna Ingryd Gonçalves
Balthazar, Janaina
Albuquerque, Marilia Silva
Caetano, Ariadiny Lima
Viel, Tania Araujo
Buck, Hudson Sousa
author_facet Nunes, Marielza Andrade
Schöwe, Natalia Mendes
Monteiro-Silva, Karla Cristina
Baraldi-Tornisielo, Ticiana
Souza, Suzzanna Ingryd Gonçalves
Balthazar, Janaina
Albuquerque, Marilia Silva
Caetano, Ariadiny Lima
Viel, Tania Araujo
Buck, Hudson Sousa
author_sort Nunes, Marielza Andrade
collection PubMed
description The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (1.2 mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer’s disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained.
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spelling pubmed-46595572015-12-02 Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease Nunes, Marielza Andrade Schöwe, Natalia Mendes Monteiro-Silva, Karla Cristina Baraldi-Tornisielo, Ticiana Souza, Suzzanna Ingryd Gonçalves Balthazar, Janaina Albuquerque, Marilia Silva Caetano, Ariadiny Lima Viel, Tania Araujo Buck, Hudson Sousa PLoS One Research Article The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer’s disease (AD) patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (1.2 mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer’s disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained. Public Library of Science 2015-11-25 /pmc/articles/PMC4659557/ /pubmed/26605788 http://dx.doi.org/10.1371/journal.pone.0142267 Text en © 2015 Nunes et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nunes, Marielza Andrade
Schöwe, Natalia Mendes
Monteiro-Silva, Karla Cristina
Baraldi-Tornisielo, Ticiana
Souza, Suzzanna Ingryd Gonçalves
Balthazar, Janaina
Albuquerque, Marilia Silva
Caetano, Ariadiny Lima
Viel, Tania Araujo
Buck, Hudson Sousa
Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title_full Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title_fullStr Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title_full_unstemmed Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title_short Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
title_sort chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of alzheimer's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659557/
https://www.ncbi.nlm.nih.gov/pubmed/26605788
http://dx.doi.org/10.1371/journal.pone.0142267
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